ea0029p829 | Endocrine tumours and neoplasia | ICEECE2012
Hui H.
, Zhang S.
, Ding W.
, Li J.
, Zhao X.
, Zuo M.
, Wang X.
, Gu W.
, Pandol S.
, Go V.
Cancer cells have shown an overexpressed fructose transporter GLUT5 and preferential utilization of fructose as compared to glucose, implicating that a fructose-based analogue would be a useful target for diagnosis and treatment of cancer. We have successfully synthesized the fructose conjugated-gefitinib compounds {N-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxy-quinazolin-6-yl]-4- [N-methyl-N-(1-deoxy-1-fructosyl)]aminobutanamide}, and examined its antitumor effic...